Since 2010, the university-run Open Data Initiative has made api.uwaterloo.ca publicly available. Easily the widest collection of data-sets, uWaterloo provides over 30 datasets, from building locations to a full list of vending machines, to the weather, wireless access points, and even Goose Spotting.
Penn Labs(formerly PennApps Labs), started in 2011, is a collaboration between the Student Government, the Provost and the Computer Science Club whose goal is to create, maintain, and improve student-run technology. APIs available to students thus far include the course registrar, dining, campus directory, campus map, transit, and course reviews.
Rutgers' Open System Solutions has run api.rutgers.edu since 2011 as a collaboration between the university and current students, making available APIS from university shuttle routes to dining schedules and campus events.
HackRU, Rutgers' student-run hackathon, helps publicize the API at each event.
ADI, the Application Development Initiative has worked since 2010 to make life easier for makers at Columbia University. data.adicu.com hosts a variety of available APIs, from courses to dining options to housing search. They also collaborated with Columbia University IT to establish the Columbia Open Data Service.